If your talking abut the SexOut Mods on LoversLab site, yes, they really do work. I have about 7 different mods plus the main SexOut.esm mod that is required to run those mods. That's on Oblivion. I also have the ones on Fallout New vegas, Fallout 3, and Skyrim. Now the games have taken a whole new meaning to "sex", or whatever you want you want to call it. I recommend trying it.
JoshNZ's mod AP goes with it also very well in both FO3 and Skyrim. In New Vegas however, the only mod that would be conflicted would be FNV Innuendo.esp. The rest are open game and do work with them very well. Whatever you do, don't add the "Rape Mod, or whatever you call it, or you'll end up being captured by raiders in FO3 and used only for sex, Fiends in New Vegas, same thing, Bandits in Skyrim, and Necromancers and bandits in Oblivion for of course, the same thing. Unless you want to try it out. Not my taste personally, but some people I guess.....You get my meaning.
In Oblivion, however, the Sexlivion, and certain pose mods are incompatible with these due to the fact they have their own poses and sexual things, mainly more scripted. Claudia's Little Secret may not work and when she offers you herself after the quest is finished, you and her may just stand there due to a conflict in scripting.